Biologics for asthma is based on phenotypes of asthma. Xolair is used for allergic asthma which is based on perennial allergens and IgE levels. There are 4 other biologics for benralizumab (Fasenra), dupilumab (Dupixent), mepolizumab (Nucala), and reslizumab (Cinqair) - treat eosinophilic asthma, a type of asthma where white blood cells know as eosinophils build up in lungs and cause inflammation. These biologics are steroid-sparing and decrease the frequency of asthma flares and subsequently ER visits and or hospitalizations. Tezepelumab (Tezspire) is another biologic that is not directed at a specific biologic marker.
Biologics are key to controlling severe asthma and can be used to avoid side effects associated with steroids, which tend to be used too often in emergency rooms and urgent care clinics.
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Important role in specific type of patients who have allergy background and failed to respond to traditional inhaler treatment despite best efforts by patient and physician. A lot of research is published, we have a lot more knowledge to approach asthma in a new way tailored to the individual patient own immune system and control their asthma the best way
Source: Vivacare
Last updated : 2/10/2023