Sublingual Immunotherapy (SLIT) - Tablets Under the Tongue - Health Tips

Thoughts on Sublingual Immunotherapy (SLIT) - Tablets Under the Tongue by Dr. Dean Mitchell, MD
October 2022

Weightlifting for immunity
In my no-needle practice, allergy drops are an important alternative to allergy shots, which so many people are afraid or loathe to get. Allergy drops work in a similar fashion to lifting weights. Just as weightlifters start out with light weights and slowly work their way up to heavier poundage as the body becomes stronger, allergy drops provide a “workout” for the body’s immune system. The body is challenged with low doses of a particular allergen until it becomes stronger through exposure and can tolerate higher doses of allergens, giving the body lasting immunity against allergy triggers.

Allergy drops versus Allergy shots
I rarely use a needle in my practice. There are so many benefits to allergy drops, also called sublingual immunotherapy, that it no longer makes sense for me to use shots. Aside from eliminating the need for unpleasant injections, allergy drops save time. With allergy shots, patients typically have to return to their doctor twice a week for several months, followed by weekly, then monthly visits for several years. Often, the patient avoids going for their shots, and the treatment is not effective. With drops, the patient has their medication in a convenient, easy to use form, and they stick to the regimen much more often.

One drop a day
With allergy drops, we create a custom-designed, diluted formula of your particular allergens. You take a little bottle home and each morning, place a drop under your tongue. Since treatment with allergy drops is so easy and convenient, people are more likely to follow through with their treatment and see results. Studies have shown that people are more likely to finish their course of therapy with drops, which means faster—and greater—tolerance to allergens.

Safer than shots
Allergy drops are also safer than injections. That’s because there are fewer mast cells and other inflammatory cells under the tongue than in your skin, where you get the injection. Fewer inflammatory cells mean you’re less likely to get an allergic reaction. Having a severe allergic response to allergy drops is rare, whereas with allergy shots, there is a small risk of anaphylaxis.

While allergy drops are commonly used in Europe, adoption has been slower here in the US. We are working towards changing that for the better.

Thoughts on Sublingual Immunotherapy (SLIT) - Tablets Under the Tongue by Dr. Mark Ebadi, MD
September 2022

This is a form of immunotherapy that involves putting drops of allergen extracts under the tongue. Many people refer to this process as “allergy drops,” and it is an alternative treatment for allergy injections. It is recommended for select children over 5 years of age, and select adults. Insurance will usually cover the cost of the office visits and allergy testing, but will not cover the cost of the drops.

Sublingual immunotherapy is not an FDA approved treatment. It is considered “off label” treatment.
What are the benefits?

  • SLIT can be effective in children to reduce symptoms of allergic rhinitis and asthma, prevent development of new allergies, and reduce the likelihood of developing future asthma.
  • SLIT can be safely administered at home.
  • Injections are avoided.


Thoughts on Sublingual Immunotherapy (SLIT) - Tablets Under the Tongue by Dr. Miriam Anand, MD, FACAAI, FAAAAI
August 2022

With just three drops under the tongue daily, our customized allergy drops are just as effective as allergy shots. The best part about allergy drops is the convenience – they can be taken at home, on the go, or anywhere in between.

Allergy drop can be self-administered. Most patients see relief in 9-12 months.

Thoughts on Sublingual Immunotherapy (SLIT) - Tablets Under the Tongue by Dr. Bruce Ball, MD, FAAAI
April 2022

The FDA has approved three different formulations of sublingual immunotherapy (SLIT), grass, ragweed, and dust mite.  These come in the form of a dissolvable tablet that is placed under the tongue daily. Similar to allergy shots, sublingual immunotherapy exposes patients to the substances which they are allergic to in a way to decrease their sensitivity over time. 

Sublingual tablets are a safe and convenient option for patients who are only allergic to grass, ragweed, and/or dust mite or for those patients who have one of these allergens as their major allergic trigger. However, most individuals are poly allergic meaning allergic to multiple allergens.

Source: Vivacare
Last updated : 2/10/2023

Sublingual Immunotherapy (SLIT) - Tablets Under the Tongue - Health Tips originally published by Vivacare