Topical PDE4 Inhibitors for Eczema

How do Topical PDE4 Inhibitors help eczema?

Eucrisa® (crisaborole) ointment is a topical PDE4 inhibitor. A PDE4 medication:

  • Reduces inflammation
  • Reduces swelling
  • Targets PDE4 enzymes deep within the skin to reduce inflammation

What do I need to know about PDE4 Inhibitors used to treat eczema?

  • PDE4 inhibitors are approved to treat mild-to-moderate eczema in adults and children ages 2 and up.
  • PDE4 inhibitors work differently than other topical treatments such as corticosteroid ointments and calcineurin inhibitors.
  • PDE4 is produced by cells in our immune system and helps the body regulate inflammation.

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Last updated : 2/6/2023

Topical PDE4 Inhibitors for Eczema originally published by Allergy & Asthma Network

Eczema